OBOC small-molecule combinatorial library encoded by halogenated mass-tags.
نویسندگان
چکیده
[reaction: see text] A bromine-/chlorine-containing mass-tag encoding strategy for a small-molecule OBOC combinatorial library is reported. The resulting MALDI FTMS isotope pattern of each tag clearly defines the component building blocks of each "hit" bead in an 1890-member demonstration library screened on-bead for binding against streptavidin via both enzyme-linked colorimetric and Quantum Dot/COPAS assays.
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ورودعنوان ژورنال:
- Organic letters
دوره 6 21 شماره
صفحات -
تاریخ انتشار 2004